Medication Support » Dr Recommended Drugs » Olanzapine


A: As with all neuroleptic drugs, olanzapine can cause tardive dyskinesia and rare, but life-threatening, neuroleptic malignant syndrome.

There are some side effects that you should be carefull :

* Aggressiveness
* akathisia inability to remain still
* dry mouth
* dizziness
* irritation
* sedation
* insomnia
* urinary retention
* orthostatic hypotension
* weight gain (90% of users experience weight gain)
* increased appetite
* runny nose
* low blood pressure
* impaired judgment, thinking, and motor skills
* impaired spatial orientation
* impaired responses to senses
* seizure
* trouble swallowing
* dental problems and discoloration of teeth
* missed periods
* problems with keeping body temperature regulated
* apathy, lack of emotion
Hope this information helps…

Q: Olanzapine?
Does olanzapine cause permanent brain changes

A: Not as far as we know. Olanzapine (Zyprexa) is a newer generation of antipsychotics, and affects brain neurochemistry, but hopefully does not cause permanent brain changes.

Q: Olanzapine has knackered my sleep up on withdrawing from it. How long till sleep gets back to normal?
Whenever I don’t take olanzapine for a day or two I am up all night and sometimes all the next day and don’t feel tired. I am wanting to withdraw from it completely so when will this effect wear off till I can sleep normally again?

PS No lectures about only doing this on the advice of your doctor etc. Thanks

A: Hi there
my finacee was put onto that pill, he came off it over a year ago, his sleeping routine is still not back to normal.
he finds it hard to doze off to sleep, can i give you some advice, withdraw slowly from the tablets as if you don;t it makes matters worse. my fiancee just stopped taking them. we were told if he started steeping down on the pills it would of been easier than just cutting off them,
it can be tricky to get back into a sleep pattern it will happen it will take time for your sleep ti return to normal.

Q: How long does it take & how effective does it take for Olanzapine stop auditry hallucinations (hearing voices)?
I have just started take olanzapine in addition to lithium & lamotrigne for my bipolar. How long should it take for is to start to work and when it does how effective is it? Cheers guys.

A: If you live in US you call TAPS for help ,they help . go to their website and study article about white noise,electro magnetism. and my view someone is playing you. taking treatment will also help you. bye.

Q: Why is my Olanzapine dose being reduced when I am feeling more depressed?
My depression is worsening yet my dose of Olanzapine is being reduced. I have severe depression, not schizophrenia.

A: This is something that you must discuss with your doctor or psychiatrist. Olanzapine is an anti psychotic as you probably know and it is fairly unusual to prescribe it for depression. Your doctor may want to reduce the dose to see how you function on less because a large dose can make you very sleepy and lethargic both of which can be symptoms of depression. Make an appointment to see your doctor to discuss the issues.
I am sorry that your depression is worsening, personally I would recommend trying not to take anti psychotics for depression. I have had to take olanzapine and risperidone and felt really miserable on both

Q: How long does insomnia last when stopping olanzapine?
I have stopped taking this medication and have not sleeped for a week and cannot see any end yet

A: it sounds like with the not sleeping and the withdrawal symptoms posted in an earlier question, you have stopped these cold turkey.

what dosage where you on to start with, did you gradually decrease them?

i really think you need to see your GP or care person and get this sorted as leaving it will only hinder your recovery.

Q: Transdermal nicotines effect on metabolism of caffeine, olanzapine and diazepam?
I have just switched from smoking 15-20 cigarettes a day to wearing a medium strength nicotine patch with low strength nicotine gum.

I am interested to know how this will effect the levels of olanzapine in my blood. Will they rise or fall? Also will this cause caffeine (low use)and diazepam(low use) to effect me more or less?

MUCH appreciated!

A: Metabolism is essentially the speed at which our body’s motor is
running. The speed at which our body burns calories is called the metabolic
rate. It’s how fast your “motor” is running when you’re still in a
reclined position or sleeping. About 60-75% of energy is expended by the
body at rest in such activities.

The metabolism is based on the number of calories we burn throughout
the day. Our body constantly burns calories to keep us going whether we
are eating, sleeping, cleaning etc. People with a lower percentage of
body fat (i.e. muscular) have a higher metabolism than others that are
less muscular because muscle uses more calories to maintain itself than
fat. Some people have a slower metabolic rate and have a harder time
staying slim. Younger persons have higher (faster) metabolism because of
the increased activity of cells. A slow metabolism actually causes to
store fat. The slower the metabolic rate, the greater the weight gains.
How to build muscles to improve metabolism? What type of exercise is
ideal that speed up metabolism so that you burn calories even at rest or
sleep? There are simple exercises that speed up the metabolism.

Causes for Low Metabolism

* Fasting
* A low calorie diet
* Snacking throughout the day on high sugared foods (candy, colas,
cakes, gum).
* Eating or drinking too much sugar containing foods.
* Lack of physical activity.
* Underactive thyroid.

Metabolism Boosters

There are some natural metabolism boosters (natural foods) that
improves your metabolism. Do not take over the counter pills containing animal
thyroid extract that claim to boost up metabolism. These products may
have side effects as diarrhea, increased heart rate, excessive
sweating, nervousness, tremors, bulging eyes, etc.

How to Improve (Speed up) Metabolism

* Do not skip any meals
* Exercise daily
* Build your muscles
* Avoid alcohol, sugar, and fastings
*Drink 8-10 glasses of water daily.
*Eat foods with high nutrition values

Q: How does Olanzapine react with Lithium , Depakote and Sertraline?
Have been treated for years with various docs and am needing SOMETHING to change. I’ve heard good things (as well as the not so good) about this mixture of meds, and wanted to know if it works for anyone.
Relevant info – I have dual working DXs of BP2 and/or BPD.
What are your meds trials and tribulations?

A: Out of the 4 you mention, I have never taken Sertaline but have taken the others. Olanzapine was horrendous for me, the weight I gained over a 6 month period was going from 180lbs to 245lbs. Depakote is ok as a mood stabiliser, but Lithium is hugely beneficial for me. I have been taking lithium since 1991. I currently take it with Seroquel (Quetiapine) and Lamictal (Lamotrigine). As you well know after taking meds for several years,m it is all trial and error to find the most beneficial and therapeutic meds that work for you.

Q: If olanzapine is not addictive, how does it improve mood?
Been on olanzapine for 5 months now and wondering if it actually does anything for me.

A: Get in touch with the doctor who prescribed it for you. That doctor would be the one who is able to tell you just exactly how it affects your mood. The way a mood stabilizer works is different from one person to another.

Q: Have you ever taken Olanzapine (or a similar med) and what was your personal experience with it?
[Or any other neuroleptic drug such as Zyprexa, or even Respiridol]

Did it effect your physical appearance (eg, skin), if so, in what ways?


A: no but i worked in a home for the mental health and some were on it, they didnt have any side affects but knowing that there is, i think it make syou very drowsy and also very distant but hey if your unsure use the web xx

Q: Will the 20mg of Olanzapine knock me out?
Hi. I am on 20mg of Olanzapine for Bipolar. I think i am on the highest dose. Will they knock me out?Will they make me sleepy?

A: you have been asking about this for 2 weeks, you should know by now

Q: i just took my olanzapine but the foil wasnt broken it had marks on the foil am i oka y? thanks?
To be honest with you it had a dent on the foil of my olanzapine. Thank you.
Thank you.

A: If the seal has not been broken or tampered with, then there is nothing to worry about.

Q: Are there any withdrawal side effects from coming off antipychotics like olanzapine?
What are your experiences?

A: That is zyprexa, isn’t it? I take 15 mg once a night for about 6 years now but never tried to not take it without doctors advice. The few times I forgot to take it I could not sleep. So my answer is you will not be able to sleep. But then I realized my mistake and called out sick to work and took my medication. I changed my name, I was Tchaikovsky, and several others but you know me because I answered your question about feeling guilty about being off work and have it in the watchlist.

Q: Anyone come off olanzapine and suffered problems sleeping from the withdrawal. How long does it last?

A: It normally subdues after a week or so. I was on Olanzapine for 2 years and changed to Seroquel last year.

Q: Can Olanzapine alone treat Manic Depression?
Hi. I have been on 15mg of Olanzapine(Zyprexa) for about 10 days now. I am 22 years and live in Scotland. The psychiatrist put me on them for high/manic mood i believe.
1)How will they make me feel?
2)Can Olanzapine treat Manic Depression alone?
3)Is 15mg a high dose?What is the maximum dose
Thanks for taking the time to read and answer.

A: I suggest you Google Zyprexa. or Olazapine.

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